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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

David R. Cheshire,Anders Åberg,Gunilla M.K. Andersson,Glen Andrews,Haydn G. Beaton,Timothy N. Birkinshaw, Nigel Boughton-Smith,Stephen Connolly,Tony R. Cook,Anne Cooper,Sally L. Cooper,David Cox,John Dixon,Nigel Gensmantel,Peter J. Hamley,Richard Harrison,Paul Hartopp,Helena Käck,Paul D. Leeson,Timothy Luker

Bioorganic & Medicinal Chemistry Letters（2011）

Cited 18|Views36
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Abstract
By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
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Key words
Nitric oxide,Nitric oxide synthases,Competitive iNOS inhibitors
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