Clinical observation of oxaliplatin plus calcium folinate,fluorouracil and pirarubicin in the treatment of advanced gastric cancer
Chinese Journal of Clinical Oncology and Rehabilitation(2007)
Abstract
Objective To study the clinical efficacy and toxicity of L-OHP plus CF,5-Fu and THP in the treatment of advanced gastric cancer.Methods All patients were treated with iv instillation of L-OHP 130 mg/(m2·d) for two hours on the first day,CF 200 mg/(m2·d) for two hours from the first day to the fifth day,5-Fu 500 mg/(m2·d) for four hours from the first day to the fifth day,and THP 45 mg/(m2·d)iv infusion on the first day,three weeks as one cycle,Results Of 32 cases of advanced gastric cancer,5 achieved CR and 12 PR,with response rate(CR+PR)of 53.1%.The Karnofsky improvement rate was 68.8%.The main toxic side effects included myelosuppression,alimentray tract reaction and neuropathy,but grade-Ⅲ leukopenia was found only in 3 cases,grade-Ⅲ alimentray tract reaction was only in 1 case.Conclusion This study showed that the chemotherapy with L-OHP combined with 5-Fu/CF and THP was effective in treatment of advanced gastric cancer with mild toxicity,and could improve the life quality of the patients.It is deserved to be investigated further.
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Key words
Pirarubicin,Oxaliplatin,Calcium folinate,Fluorouracil,Gastric neoplasm
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