奥硝唑注射液与头孢噻肟钠的配伍稳定性考察
Pharmaceutical Care and Research(2006)
Abstract
目的:采用RP-HPLC法考察4℃、25℃、37℃下24 h内奥硝唑注射液与注射用头孢噻肟钠的配伍稳定性。方法:采用Shimpack ODS色谱柱(4 mm×150 mm,5μm),流动相为甲醇∶水(60∶40),流速为0.5 mL/min,柱温25℃,检测波长为294 nm。结果:含奥硝唑50μg/mL和头孢噻肟钠100μg/mL的配伍液在4℃8 h、25℃4 h、37℃1 h内,外观及pH值无明显变化,奥硝唑的含量变化在5%以下,头孢噻肟钠的水解速率符合一级反应规律。结论:奥硝唑注射液与注射用头孢噻肟钠的配伍液在配伍后4℃8 h内、25℃4 h内、37℃1 h内可使用。
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Key words
Cefotaxime sodium,Chromatography,Compatibility,Drug stability,High pressure liquid,Ornidazole
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