MDMA related neuro-inflammation and adenosine receptors
Neurochemistry International(2022)
摘要
3,4-methylenedioxymethamphetamine (MDMA) is a world-wide abused psychostimulant, which has the neurotoxic effects on dopaminergic and serotonergic neurons in both rodents and non-human primates. Adenosine acts as a neurotransmitter in the brain through the activation of four specific G-protein-coupled receptors and it acts as a neuromodulator of dopamine neurotransmission. Recent studies suggest that stimulation of adenosine receptors oppose many behavioral effects of methamphetamines.
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关键词
Adenosine receptors,Ecstasy,MDMA,Neuroinflammation
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