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Synthesis of anti-microtubule N-(2-Arylindol-7-yl)benzenesulfonamide derivatives and their antitumor mechanisms.

Chun-Tang Chiou,Grace Shiahuy Chen,Meng-Ling Chen,Huoming Li,Lei Shi,Xiang-Hong Huang, Wei-Ming Dai,Ji-Wang Chern

CHEMMEDCHEM（2010）

Cited 16|Views21
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Abstract
Breaking the cycle: A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone-resistant prostate cancer PC-3 cells, induced G2/M-phase arrest, and induced apoptosis through a caspase-dependent pathway.
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Key words
antimitotic agents,apoptosis,benzenesulfonamides,cytotoxicity,microtubules
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