Nanog在肺癌中的表达及对吉西他滨联合顺铂化疗疗效的影响
Journal of Modern Medicine & Health(2013)
Abstract
目的探讨中晚期(Ⅲ、Ⅳ期)肺癌患者Nanog的表达及对吉西他滨联合顺铂化疗疗效的影响。方法采用免疫组化法检测62例肺癌患者Nanog的表达情况,研究其表达情况对吉西他滨联合顺铂化疗疗效的影响。结果 62例晚期肺癌患者中Nanog表达阳性30例(48.4%),吉西他滨联合顺铂化疗有效组32例患者中Nanog表达阳性9例(28.1%),阴性23例(71.9%);无效组30例患者中Nanog表达阳性21例(70.0%),阴性9例(30.0%)。无效组患者Nanog表达阳性率明显高于有效组(χ2=10.872,P=0.001)。结论 Nanog表达增强可导致肺癌患者对吉西他滨联合顺铂化疗不敏感,检测Nanog对临床制订肺癌个体化治疗方案有一定参考价值。
MoreTranslated text
Key words
Nanog,Gene expression,Treatment outcome,Chemotherapy,Lung neoplasms
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined