Bioinformatics and Experimental Design for Biomarker Discovery
Proteomics of Human Body Fluids(2007)
摘要
Proteomics is supremely well suited to the discovery of biomarkers in human body fluids. However, the diversity of the human
population and the multistep nature of most proteomic techniques require great care to be taken in experimental design and
data analysis. This chapter out-lines strategies for biomarker discovery, using 2D polyacrylamide gel electrophoresis or other
proteomic technologies, and explores issues of analytical and biological variation, data quality, and statistical analysis.
Particular attention is given to the issue of experimental design and how this can influence the statistical outcomes of biomarker
discovery efforts.
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关键词
experimental design,biomarker,statistics.,variance,bioinformatics,proteomics
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