3-Chloro-4-Carboxamido-6-Arylpyridazines As A Non-Peptide Class Of Interleukin-1 Beta Converting Enzyme Inhibitor

The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1 beta converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k(obs)/[I] = 355 M-1 s(-1). A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described. (C) 1997 Elsevier Science Ltd.