Development of a new class of benzoylpyrrole-based PPARα/γ activators.

Kantaro Ushiroda,Katsunori Maruta,Makoto Kitoh,Kiyotaka Iwai,Jun Nagamine,Atsushi Tsuchida,Mutsuo Taiji,Ryu Nagata

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

TGF-β signaling pathway inhibitor and potential anti-nephropathic agent SMP-534 was successfully converted to a new class of benzoylpyrrole-based PPARα/γ activators as an anti-diabetic agent. Compound 10sNa showed a favorable blood glucose-lowering effect without body weight gain.

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关键词

PPARα/γ modulator,Type 2 diabetes

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