米非司酮配伍甲基睾丸素治疗围绝经期妇女子宫肌瘤的疗效观察
Journal of Clinical and Experimental Medicine(2008)
Abstract
目的:观察米非司酮配伍甲基睾丸素治疗围绝经期子宫肌瘤的临床疗效。方法:40岁以上有异常子宫出血的子宫肌瘤患者57例随机分为:Ⅰ治疗组31例,给米非司酮12.5mg/日口服、甲基睾丸素5mg/日含服,连续三个月;Ⅱ对照组26例,甲基睾丸素7.5mg/日含服,连续三个月。结果:治疗期间,Ⅰ组均发生闭经(100%),其中15例(48.4%)直接进入绝经期,治疗后瘤体平均缩小48.2%(P<0.01);Ⅱ组闭经者6例,其中5例(19.2%)绝经,另16例出血减少,经期缩短,瘤体平均缩小12.5%(P>0.05)。结论:米非司酮配伍甲基睾丸素,其对抗雌孕激素的作用对围绝经期子宫肌瘤是较为安全而有效的保守疗法。
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Key words
Uterine myoma,Methytestosterone,Mifepristone
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