Cell-specific regulation of the pro-survival Brn-3b transcription factor by microRNAs.
Molecular and Cellular Neuroscience(2010)
Abstract
We have previously shown that the Brn-3b transcription factor is subjected to post-transcriptional gene regulation by specific microRNAs (mir-23 and mir-214) in the ND7 and SHSY-5Y neuronal cell lines (Calissano et al., 2007). As Brn-3b plays an essential role in the survival of retinal ganglion cells in the rat (Erkman et al., 1996; Gan et al., 1996; Gan et al., 1999; Erkman et al., 2000), we wanted to investigate whether mir-23 and mir-214 are expressed and target Brn-3b mRNA in a retinal ganglion cell line (RGC-5) thus potentially killing the cells expressing it.
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Key words
Brn-3b,MicroRNA,Transcription factor,Retinal ganglion cells,Pro-survival,Neuron
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