The Next Wave
CELLULAR SIGNALLING(2015)
摘要
Recent years have seen an exponentially increasing interest in the molecular mechanisms of signal transduction. Much of the focus has been on protein tyrosine kinase-mediated signalling, while the study of protein tyrosine phosphatases has lagged behind. We predict that the phosphatases will become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the-art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in T lymphocyte activation. (C) 1999 Elsevier Science Inc.
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关键词
protein tyrosine phosphatases,T cell activation,T cell antigen receptor,protein tyrosine kinases,T lymphocytes
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