Design and optimisation of potent gp120-CD4 inhibitors.

Thien-Duc Tran,Fiona M Adam,Frederick Calo,David R Fenwick,Juin Fok-Seang,Iain Gardner,Duncan A Hay,Manos Perros,Jaiessh Rawal,Donald S Middleton,Tanya Parkinson,Christopher Pickford,Michelle Platts,Amy Randall,Peter T Stephenson,Hannah Vuong,David H Williams

Bioorganic & Medicinal Chemistry Letters（2009）

引用 14|浏览25

暂无评分

摘要

The synthesis and SAR of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36.

查看译文

关键词

HIV-1,gp120-CD4 inhibitor,Antiviral

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要