Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.

Cynthia Aki,Jianping Chao,Johan A Ferreira,Michael P Dwyer,Younong Yu,Jianhua Chao,Robert J Merritt,Gaifa Lai,Minglang Wu,R William Hipkin,Xuedong Fan,Waldemar Gonsiorek,James Fosseta,Diane Rindgen,Jay Fine,Daniel Lundell,Arthur G Taveras,Purakkattle Biju

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2009）

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摘要

A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various amide modi. cations and substitution on the left side phenyl ring were prepared and found to show significant inhibitory activities towards both CXCR2 and CXCR1 receptors. (C) 2009 Elsevier Ltd. All rights reserved.

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关键词

Diaminocyclobutenediones,CXCR2 receptor antagonist,Amide modification

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