Neural tube morphogenesis
CURRENT OPINION IN GENETICS & DEVELOPMENT(1997)
摘要
Many important findings in the past year have helped to identify multiple cellular interactions and signals in vertebrates that govern induction of neuroectoderm, its patterning, neural tube formation, and the subsequent differentiation of neurons. For example, the neural inducers have been shown to function as inhibitors of BMP signaling, ther oles of bone morphogenetic proteins and Sonic hedgehog during dorso-ventral specification of the neural tube have been further elucidated and the realization of a dorso-ventral inversion of the body axis contributed to a better understanding of evolutionarily related genes and functions between vertebrates and invertebrates.
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关键词
dll delta-like,hh hedgehog,shh sonic hedgehog,bmp bone morphogenetic protein,cns central nervous system,sog short gastrulation,flik follistatin-like,dpp decapentaplegic,ptc patched,nccs neural crest cells,sim single-minded,bone morphogenetic protein,central nervous system,neural crest cell
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