Peutz-Jegher syndrome.

Peutz-Jeghers syndrome(PJS) is an autosomal dominantly inherited disease characterized by hamartomatous gastrointestinal polyposis and melanin spots on the buccal mucosa,hands,feet and lips,and also other system tumors.The STK11/LKB1 gene germline mutation has been identified as being responsible for PJS.Also,the mutation and deletion of FHIT gene also play a part in the state of the PJS illness and its cancerization.And furthermore,there maybe another gene,maps 19p13.3.The treatment for the hamartomatous gastrointestinal polyposis should be on the basis of the polypus type.