TNFα converting enzyme
Metalloproteinases as Targets for Anti-Inflammatory Drugs(1999)
Abstract
Tumor necrosis factor a (TNFα) is a pleiotropic cytokine that mediates inflammatory and apoptotic processes by binding to
two different receptors and thereby initiating complex signaling transduction pathways [1]. While TNFa has been studied since the earlier part of this century, the purification and cloning of this protein in 1985
[2 – 5] precipitated a decade of intensive research. These efforts demonstrated the cross-disciplinary significance of this molecule
and gave insight into the signaling pathways that initiated TNFα transcription, the unique control of its translation and
the TNF receptors that bind the secreted, 17 kDa molecule. These receptors reside on cells of nearly every tissue and, in
turn, transduce the signals that result in changes in cell behavior.
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Key words
enzyme
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