神经胶质瘤的表观遗传学机制
Journal of Molecular Diagnostics and Therapy(2011)
Abstract
神经胶质瘤是颅内最常见的一种恶性肿瘤,它的发生、发展与表观遗传修饰密切相关。本文着重介绍了近年来神经胶质瘤发生、发展过程中DNA甲基化异常、miRNA表达异常、组蛋白修饰异常三种主要的表观遗传修饰方式的研究进展。由于表观遗传修饰引起的改变可以通过药物逆转,本文进而探讨了基于表观遗传修饰机制的潜在药物治疗神经胶质瘤的前景。
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Key words
Histone modification,miRNA,DNA methylation,Glioma,Epigenetic
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