Effect of resuscitation after selective cerebral ultraprofound hypothermia on expressions of nerve growth factor and glial cell line-derived neurotrophic factor in the brain of monkey
Neuroscience bulletin(2008)
Abstract
Objective To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. Methods The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05. Results The expressions of NGF and GDNF in the group B were significantly higher than those in the group A ( P < 0.05). Conclusion NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.
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Key words
nerve growth factor,glial cell line-derived neurotrophicfactor,ultraprofound hypothermic circulatory arrest,resuscitation,monkey brain,R654.1,神经生长因子,胶质细胞源性神经营养因子,超深低温断血流,复苏,猴脑
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