Clinical trials.
The New England journal of medicine(1978)
Abstract
The spectrum of evidence imparted by the different clinical research designs ranges from ecological studies through observational
epidemiological studies to randomized control trials (RCTs). This chapter addresses the definition of clinical research, the
major aspects of clinical trials eg ethics, randomization, masking, recruitment and retention of subjects enrolled in a clinical
trial, patients/subjects lost to follow-up during the trial etc. Although this chapter focuses on the weaknesses of clinical
trials, it is emphasized that the randomized, placebocontrolled, double blind clinical trial is the design that yields the
greatest level of scientific evidence.
A researcher is in a gondola of a balloon that loses lift and lands in the middle of afield near a road. Of course, it looks
like the balloon landed in the middle of nowhere. As the researcher ponders appropriate courses of action, another person
wanders by. The researcher asks, ‘Where am I?’ The other person responds, ‘You are in the gondola of a balloon in the middle
of a field.’ The researcher comments, ‘You must design clinical trials.’ ‘Well, that’ amazing, how did you know?’ ‘Your answer
was correct and precise and totally useless.’
MoreTranslated text
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined