PPARγ基因的多态性与2型糖尿病的相关性研究进展

Contemporary Medicine(2008)

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Abstract
PPAR是一类由配体激活的核转录因子,可分为α,β,γ三种类型.PPARγ具有多种生物学效应,在脂肪分化,脂代谢、胰岛素抵抗、2型糖尿病等起重要作用.PPARγ的常见多态性影响胰腺β细胞功能,导致胰岛素分泌及外周组织对胰岛素敏感性的改变.它与2型糖尿病的发病风险相关联.
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Key words
gene polymorphism,peroxisome proliferator2activated receptorγ,type 2 diabetes
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