Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

•MCRS1 loss in hepatocytes deregulates the expression of BA transporters, causing perturbation of BA flow and cirrhosis.•Re-expression of the BA transporter NTCP in MCRS1-depleted hepatocytes restores the BA flow and prevents cirrhosis.•Accumulation of BAs in liver sinusoids activates liver fibroblasts via FXR leading to fibrosis.•MCRS1 loss increases histone acetylation of BA transporter genes, altering their expression levels.•MCRS1 and NTCP expression correlates with fibrotic marks in human cirrhosis samples.