COPD机械通气病人撤参数分析

Contemporary Medicine(2008)

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Abstract
目的研究闭合气道压(P0.1)、急性生理与慢性健康状况(APACHE)Ⅱ评分、血浆白蛋白(Alb)水平、浅快呼吸指数(RSBI)在慢性阻塞性肺病(COPD)机械通气病人撤机时的指导意义。方法对126例符合临床撤机条件的COPD机械通气病人测定P0.1、APACHEⅡ评分、Alb水平、RSBI值,然后进行撤机试验,并观察上述指标与撤机结果之间的关系。结果撤机成功组76例,P0.1值为(2.20±0.56)cmH2O、APACHEⅡ评分为22.3±2.7、Alb值为(33.4±4.9)g/L、RSBI值为(64.17±25.64)bpm/L;撤机失败组50例,P0.1值为(4.25±0.71)cmH2O、APACHEⅡ评分为29.8±3.2、Alb值为(26.5±8.4)g/L、RSBI值为(87.62±26.32)bpm/L。撤机失败组的P0.1值、APACHEⅡ评分、RSBI明显高于成功组("P<0.05")。撤机成功组的Alb值明显高于撤机失败组("P<0.05")。撤机成功组中,70例P0.1≤6cmH2O,67例RSBI≤105bpm/L,6例P0.1>6cmH2O,9例RSBI>105bpm/L;失败组中,17例P0.1≤cmH2O,31例RSBI≤105bpm/L,33例P0.1>6cmH2O,19例RSBI>105bpm/L。以P0.1≤cmH2O、RSBI≤105bpm/L为标准,其预测撤机成功的灵敏度分别为92.11%、88.16%,特异度分别为66.0%、38.0%。结论P0.1、APACHEⅡ评分、Alb、RSBI对COPD机械通气病人的撤机有一定指导意义。
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Key words
Chronic obstructive pulmonary disease(COPD),Rapid - shallow - breathing index(RSBI),Weaning from mechanical ventilation,albumin(Alb),acute physiology and chronic health evaluation II(APACHE II),airway occlusion pressure (P0.1)
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