Composite module analyst: tool for prediction of DNA transcription regulation. testing on simulated data
ADVANCES IN NATURAL COMPUTATION, PT 2, PROCEEDINGS(2005)
Abstract
Functionally related genes involved in the same molecular-genetic, biochemical, or physiological process are often regulated coordinately Such regulation is provided by precisely organized binding of a multiplicity of spe cial proteins- transcription factors to their target sites (cis-elements) in regulatory regions of genes. Cis-element combinations provide a structural basis for the generation of unique patterns of gene expression. Here we present new method based on genetic algorithm for prediction of class-specific composite modules in promoters of functionally related or coexpressed genes and it's testing on simulated data.
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Key words
physiological process,coexpressed gene,genetic algorithm,class-specific composite module,regulatory region,simulated data,cis-element combination,dna transcription regulation,new method,gene expression,functionally related gene,composite module analyst,transcription factor,transcription regulation,molecular genetics
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