Detection of the biotin-streptavidin interaction by exploiting surface stress changes on ultrathin Si membranes

Vasiliki Tsouti,Christos Boutopoulos,Peristera Andreakou,Marina Ioannou,Ioanna Zergioti,Dimitris Goustouridis,Dimitris Kafetzopoulos,Dimitris Tsoukalas,Pascal Normand,Stavros Chatzandroulis

MICROELECTRONIC ENGINEERING（2009）

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摘要

The detection of the biotin-streptavidin interaction is presented based on surface stress changes of functionalized Si membranes. During the biomolecular interaction, the surface stress of the functionalized membranes alters resulting in their deflection and finally in capacitance variations. The biological interaction on the sensors surface was verified after each experiment using fluorescent microscopy. Successful detection of 21nM of streptavidin using 3.55mM biotin probes is presented.

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关键词

surface stress,functionalized membranes alters,ultrathin si membrane,biotin-streptavidin interaction,biological interaction,biotin probe,successful detection,biomolecular interaction,functionalized si membrane,surface stress change,sensors surface,fluorescence microscopy,biosensor

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