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There are two research focuses in my laboratory: the regulation of glutamate transporters and neuroprotection.
Glutamate is a major excitatory neurotransmitter. Glutamate is also a toxin when its extracellular concentration is high. Glutamate transporters are membrane proteins, which transport glutamate from extracellular to intracellular space under physiological conditions. This process has been found to play an important role in maintaining low extracellular glutamate level. Five glutamate transporters have been characterized so far. We are interested in studying by what and how the activity and protein expression of glutamate transporters can be regulated. We use cell culture (including C6 cells, glial and neuronal cultures) and brain slices and employ pharmacology, physiology and biochemistry methods in our studies.
Glutamate is a major excitatory neurotransmitter. Glutamate is also a toxin when its extracellular concentration is high. Glutamate transporters are membrane proteins, which transport glutamate from extracellular to intracellular space under physiological conditions. This process has been found to play an important role in maintaining low extracellular glutamate level. Five glutamate transporters have been characterized so far. We are interested in studying by what and how the activity and protein expression of glutamate transporters can be regulated. We use cell culture (including C6 cells, glial and neuronal cultures) and brain slices and employ pharmacology, physiology and biochemistry methods in our studies.
Research Interests
Papers共 341 篇Author StatisticsCo-AuthorSimilar Experts
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INTERNATIONAL JOURNAL OF SURGERYno. 1 (2024): 253-260
Anesthesiologyno. 4 (2024): 729-741
JAMA SURGERYno. 2 (2024): 127-128
Behavioural brain research (2023): 114577-114577
Rui Mao,Shihao Xu,Guangwen Sun,Yingying Yu,Zhiyi Zuo, Yuanyuan Wang,Kun Yang,Zhen Zhang,Wenqiong Yang
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