He has major scientific interest in neurovascular diseases, specifically aneurysms and vascular malformations. He has been implicated in clinical and experimental research related to aneurysm disease understanding and therapy.
Intracranial aneurysms affect approximately 2-3% of the general population and they represent a significant healthcare burden. Aneurysm risk analysis represents thus an important step in the management of the disease. Aneurysm patho-biology has been recently linked to intravascular hemodynamics. Factors like wall shear stress and flow patterns have been shown to influence the biological response of vessel and aneurysm structural elements like endothelium, smooth muscle cells and extracellular matrix. Dr. Kulcsár has interest in further understanding the role of hemodynamics in the natural evolution of intracranial aneurysms.