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We have been working in the field of computational biology and bioinformatics on protein-protein interactions and protein dynamics; specifically on:
Protein-protein interfaces: the regions where two proteins bind each other. We have extensively studied the structural (geometrical) and physico-chemical properties of interfaces. We have two interface datasets (Keskin et al, 2004 and Tuncbag et al 2009, PRINT). In these datasets, the protein interfaces are classified as Type I, II and III. She showed that as expected if two proteins are similar, they bind through similar interfaces (type I). She also emphasized that, unexpectedly, even if two proteins are dissimilar, they might still use similar type of interfaces (type II).
Protein-protein interfaces: the regions where two proteins bind each other. We have extensively studied the structural (geometrical) and physico-chemical properties of interfaces. We have two interface datasets (Keskin et al, 2004 and Tuncbag et al 2009, PRINT). In these datasets, the protein interfaces are classified as Type I, II and III. She showed that as expected if two proteins are similar, they bind through similar interfaces (type I). She also emphasized that, unexpectedly, even if two proteins are dissimilar, they might still use similar type of interfaces (type II).
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Scientific reportsno. 1 (2024): 1239-1239
JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 8 (2024): 2979-2987
2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)pp.1-7, (2023)
Aslı İmran Yılmaz,Sevgi Pekcan,Tuğba Şişmanlar Eyüboğlu,Melih Hangül, Hüseyin Aslan,Ayşe Ayzıt Kılınç,Haluk Çokuğraş,Elif Arık,Özlem Keskin,Ali Özdemir, Murat Ersoy,Ali Özgür Ersoy,
Research Square (Research Square) (2023)
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Clinical immunology (Orlando, Fla.) (2023): 109691-109691
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