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RNA Interference in Insects
RNA interference (RNAi) has been known as common machinery for sequence-specific gene silencing through the RNAi pathway in eukaryotic organisms. However, there are significant differences in the efficiency of RNAi among different taxonomic groups of insects. For example, coleopterans, hemipterans and orthopterans have a robust RNAi response whereas lepidopterans and dipterans often show poor RNAi response. Such differences could be in part due to different stabilities of double-stranded RNA (dsRNA) and different efficiencies in cellular uptake of dsRNA among different insects. Our studies are to address the questions related to the stability and cellular uptake of dsRNA in different insects. Our studies also focus on the identification of candidate genes and the development of dsRNA delivery methods (e.g., nanoparticle-based approaches) potentially to be used for RNAi-based management of insect pests. Our studies are expected to provide new insights into possible mechanisms leading to differential RNAi efficiencies among different insects and help researchers develop effective RNAi-based technologies for insect pest management.
Insecticide Detoxification and Resistance
The most significant challenge for successful control of insect pests by using chemical insecticides and transgenic plants expressing insecticidal molecules is the development of resistance to these control agents in insect populations. Although a large number of the genes potentially involved in conferring insecticide toxicity, detoxification and resistance have been revealed from various insect species based on the genomics research, our knowledge on the role of these genes essential to insect pest management has been very limited. Our research focuses on: 1) functional analysis of insecticide target genes (e.g., acetylcholinesterases); 2) roles and up-regulations of detoxification genes (e.g., cytochrome P450 monooxygenases, carboxylesterases and glutathione S-transferases); and 3) molecular analysis of the genes possibly involved in conferring Bacillus thuringiensis (Bt) toxicity and resistance in insects. We expect that these studies will help researchers develop effective strategies for insect pest control and resistance management.
Research Interests
Papers共 877 篇Author StatisticsCo-AuthorSimilar Experts
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ENVIRONMENTAL ENTOMOLOGYno. 1 (2024): 127-142
Crop protectionpp.106752-106752, (2024)
Jennifer Abshire, Rachel Harman,Alexander Bruce, Samantha Gillette,Jacqueline M. Maille,Sabita Ranabhat,Erin D. Scully,Kun Yan Zhu,Alison R. Gerken,William R. Morrison
Environmental entomology (2024)
Pest management science (2024)
PEST MANAGEMENT SCIENCEno. 4 (2024): 1702-1716
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2024)
Pesticide Biochemistry and Physiology (2024): 105953-105953
Soheila Fatehi,Michael Aikins, Thomas W Philips,Susan Brown,Kun Yan Zhu,Erin D Scully,Yoonseong Park
Insectsno. 3 (2023): 220
ENTOMOLOGIA GENERALISno. 1 (2023): 167-175
RNA biologyno. 1 (2023): 323-333
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Author Statistics
#Papers: 912
#Citation: 9632
H-Index: 49
G-Index: 85
Sociability: 6
Diversity: 1
Activity: 90
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