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My research interests lie broadly at the interface of chemistry and biology. The main thrust of my group is to discover novel enzymes and antimicrobial targets. The two main research projects in our lab are:
Project 1. Soil and marine microorganisms produce a wide variety of secondary metabolites with spectacular chemical structure and potent biological activity. Relying on a genome-guided approach, we focus on discovering novel biosynthetic enzymes and secondary metabolites encoded by unusual biosynthetic gene clusters. After isolating phylogenetically unique soil and marine microbes from the tropic environment of South East Asia, we usually sequence and mine the genome of the microbes to identify novel biosynthetic pathways. We employ a variety of genetic, biochemical, and synthetic biology tools to manipulate the biosynthetic gene clusters to produce (and modify) the secondary metabolites and characterize the function and mechanism of the novel biosynthetic enzymes. We expect the research work to yield novel bioactive natural products with potential therapeutic values and enzymes that can be exploited as biocatalysts.
Project 2. Cyclic dinucleotides (e.g., c-di-GMP and c-di-AMP) have emerged as prominent messengers in many multidrug-resistant pathogenic bacteria in recent years. Cyclic dinucleotides contribute to bacterial pathogenesis by mediating such important processes as virulence expression, antibiotic resistance, and biofilm formation. Accumulating evidence suggests that the cellular level of cyclic dinucleotides is controlled in a spatiotemporal manner by a complex network of enzymes and effector proteins. We are conducting biochemical, structural, and transcriptomic studies to understand cyclic dinucleotide-mediated mechanisms that underpin bacterial infection and antibiotic resistance. Given the vital role played by the cyclic nucleotides in both acute and chronic bacterial infection, we expect the research to disclose novel signaling proteins and pathways that can be targeted for developing antimicrobial and biofilm-controlling agents.
A full list of my publications can be found at https://scholar.google.com/citations?hl=en&user=F-DuOAkAAAAJ&view_op=list_works.Please contact me directly (zxliang@ntu.edu.sg) if you are interested in joining us.
Project 1. Soil and marine microorganisms produce a wide variety of secondary metabolites with spectacular chemical structure and potent biological activity. Relying on a genome-guided approach, we focus on discovering novel biosynthetic enzymes and secondary metabolites encoded by unusual biosynthetic gene clusters. After isolating phylogenetically unique soil and marine microbes from the tropic environment of South East Asia, we usually sequence and mine the genome of the microbes to identify novel biosynthetic pathways. We employ a variety of genetic, biochemical, and synthetic biology tools to manipulate the biosynthetic gene clusters to produce (and modify) the secondary metabolites and characterize the function and mechanism of the novel biosynthetic enzymes. We expect the research work to yield novel bioactive natural products with potential therapeutic values and enzymes that can be exploited as biocatalysts.
Project 2. Cyclic dinucleotides (e.g., c-di-GMP and c-di-AMP) have emerged as prominent messengers in many multidrug-resistant pathogenic bacteria in recent years. Cyclic dinucleotides contribute to bacterial pathogenesis by mediating such important processes as virulence expression, antibiotic resistance, and biofilm formation. Accumulating evidence suggests that the cellular level of cyclic dinucleotides is controlled in a spatiotemporal manner by a complex network of enzymes and effector proteins. We are conducting biochemical, structural, and transcriptomic studies to understand cyclic dinucleotide-mediated mechanisms that underpin bacterial infection and antibiotic resistance. Given the vital role played by the cyclic nucleotides in both acute and chronic bacterial infection, we expect the research to disclose novel signaling proteins and pathways that can be targeted for developing antimicrobial and biofilm-controlling agents.
A full list of my publications can be found at https://scholar.google.com/citations?hl=en&user=F-DuOAkAAAAJ&view_op=list_works.Please contact me directly (zxliang@ntu.edu.sg) if you are interested in joining us.
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BIOTECHNOLOGY JOURNALno. 2 (2024): e2300542-e2300542
Sean Qiu En Lee,Guang-Lei Ma,Hartono Candra, Srashti Khandelwal,Li Mei Pang,Zhen Jie Low,Qing Wei Cheang,Zhao-Xun Liang
ACS SYNTHETIC BIOLOGYno. 4 (2024): 1259-1272
Tianfang Cheng,Qing Wei Cheang,Linghui Xu,Shuo Sheng, Zhaoting Li,Yu Shi, Huiyan Zhang,Li Mei Pang,Ding Xiang Liu,Liang Yang,Zhao-Xun Liang,Junxia Wang
The Journal of biological chemistryno. 3 (2024): 105741-105741
Yanghui Liao,Xue-Jiao Wang,Guang-Lei Ma,Hartono Candra,Sean Lee Qiu En, Srashti Khandelwal,Zhao-Xun Liang
CHEMBIOCHEMno. 1 (2024)
FEMS microbiology reviewsno. 3 (2023)
FRONTIERS IN MICROBIOLOGY (2022): 1012115
Guang-Lei Ma,Lingyi Xin,Yanghui Liao, Zhi-Soon Chong,Hartono Candra,Li Mei Pang, Sean Qiu En Lee,Martin Muthee Gakuubi,Siew Bee Ng,Zhao-Xun Liang
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