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个人简介
Dr. Zemin Yao is Professor of Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa. Born in Shanghai, China, Dr. Yao obtained his MSc and PhD in Biochemistry at University of British Columbia, and his postdoctoral research training at Gladstone Institute of Cardiovascular Diseases of University of California, San Francisco. In 1991, Dr. Yao was appointed as Assistant Professor of Biochemistry, University of Alberta, where he established his first independent research program at the Lipid and Lipoprotein Research Group of University of Alberta with support from Alberta Heritage Foundation for Medical Research, Heart and Stroke Foundation of Canada, Heart and Stroke Foundation of Alberta, and Medical Research Council of Canada (now the Canadian Institutes of Health Research). In 1994, Dr. Yao joined University of Ottawa Heart Institute to direct the Molecular and Cell Biology Laboratory of the CIHR Lipoprotein and Atherosclerosis Group. From 2002 through 2013, Dr. Yao was appointed as Chairman of the Department of Biochemistry, Microbiology and Immunology of the University of Ottawa. In 2014-2015, Dr. Yao was Visiting Scholar of Harvard University in the Department of Chemistry and Chemical Biology. Currently, Dr. Yao is Visiting Professor of Shanghai University of Traditional Chinese Medicine and Distinguished Visiting Professor of Guangzhou University of Chinese Medicine.
Dr. Yao has a broad research interest in the metabolism of lipids and lipoproteins, and in the relationships between various diseases and the abnormalities in the metabolism of lipoproteins and lipoprotein receptors. Lipoproteins are microscopic particles that carry the majority of cholesterol and triglycerides in the circulation. Elevation of the disease-causing lipoproteins, known as LDL or “bad cholesterol,” is often associated with metabolic syndromes (such as diabetes and obesity) and with premature coronary heart disease. Dr. Yao has investigated the lipid and protein factors (such as apoB, apoC3, and hepatic lipase) that regulate the biosynthesis of LDL, and his research has yielded insights into the molecular mechanisms responsible for various diseases, including familial defective apoB (that causes high blood concentration of LDL), familial hypobetalipoproteinemia and familial abetalipoproteinemia (both have abnormally low blood concentration of LDL), and familial combined hyperlipidemia (caused by overproduction of disease-causing lipoproteins).
Dr. Yao is currently investigating several proteins that are produced in the liver and their roles in the development of non-alcoholic fatty liver diseases and hypertriglyceridemia. His research directly relates to the development of pharmacological interventions in the prevention and treatment of chronic and metabolic disorders.
Dr. Yao´s research utilizes modern molecular and cellular biology techniques including genetically inactivating (known as “knockout”) or expressing (known as transgenic) specific genes in mice, and various microscopic imaging techniques including live cell imaging and tomographic electron microscopy.
Dr. Yao’s research program has been funded through operating grants from the Canadian Institutes of Health Research, grant-in-aids from the Heart and Stroke Foundation of Canada, research & development grant from the National Science and Engineering Research Council of Canada. Dr. Yao has received numerous recognitions and awards from international and national organizations. He was the recipient of the Alberta Heritage Foundation for Medical Research Scholarship Award, the McDonald Scholarship and Carrier Investigator Award of Heart and Stroke Foundation of Canada, and the Scientist Award and Senior Investigator Award of the Medical Research Council of Canada and Canadian Institutes of Health Research. Dr. Yao was also the recipient of the Senior Investigator Award of the Canadian Lipoprotein Conference, and the recipient of Ottawa Life Science Council Achievement Award in Basic Research. Dr. Yao publishes his experimental results in scientific journals and regularly presents his discoveries at national and international conferences. Dr. Yao is also an active teacher who mentors postgraduate students in the laboratory and teaches undergraduate, postgraduate, and medical school students annually.
Dr. Yao has a broad research interest in the metabolism of lipids and lipoproteins, and in the relationships between various diseases and the abnormalities in the metabolism of lipoproteins and lipoprotein receptors. Lipoproteins are microscopic particles that carry the majority of cholesterol and triglycerides in the circulation. Elevation of the disease-causing lipoproteins, known as LDL or “bad cholesterol,” is often associated with metabolic syndromes (such as diabetes and obesity) and with premature coronary heart disease. Dr. Yao has investigated the lipid and protein factors (such as apoB, apoC3, and hepatic lipase) that regulate the biosynthesis of LDL, and his research has yielded insights into the molecular mechanisms responsible for various diseases, including familial defective apoB (that causes high blood concentration of LDL), familial hypobetalipoproteinemia and familial abetalipoproteinemia (both have abnormally low blood concentration of LDL), and familial combined hyperlipidemia (caused by overproduction of disease-causing lipoproteins).
Dr. Yao is currently investigating several proteins that are produced in the liver and their roles in the development of non-alcoholic fatty liver diseases and hypertriglyceridemia. His research directly relates to the development of pharmacological interventions in the prevention and treatment of chronic and metabolic disorders.
Dr. Yao´s research utilizes modern molecular and cellular biology techniques including genetically inactivating (known as “knockout”) or expressing (known as transgenic) specific genes in mice, and various microscopic imaging techniques including live cell imaging and tomographic electron microscopy.
Dr. Yao’s research program has been funded through operating grants from the Canadian Institutes of Health Research, grant-in-aids from the Heart and Stroke Foundation of Canada, research & development grant from the National Science and Engineering Research Council of Canada. Dr. Yao has received numerous recognitions and awards from international and national organizations. He was the recipient of the Alberta Heritage Foundation for Medical Research Scholarship Award, the McDonald Scholarship and Carrier Investigator Award of Heart and Stroke Foundation of Canada, and the Scientist Award and Senior Investigator Award of the Medical Research Council of Canada and Canadian Institutes of Health Research. Dr. Yao was also the recipient of the Senior Investigator Award of the Canadian Lipoprotein Conference, and the recipient of Ottawa Life Science Council Achievement Award in Basic Research. Dr. Yao publishes his experimental results in scientific journals and regularly presents his discoveries at national and international conferences. Dr. Yao is also an active teacher who mentors postgraduate students in the laboratory and teaches undergraduate, postgraduate, and medical school students annually.
研究兴趣
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World Journal of Traditional Chinese Medicineno. 1 (2022): 77-86
WORLD JOURNAL OF GASTROENTEROLOGYno. 38 (2020): 5812-5821
Yuanyuan Qin,Flora Ting,Mee J. Kim, Jacob Strelnikov,Joseph Harmon,Feng Gao,Andrea Dose,Ba-Bie Teng, Mohsen Amir Alipour,Zemin Yao,Rosanne Crooke,Ronald M. Krauss,
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