基本信息
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Bio
My core research is directed at understanding how muscle satellite cells are regulated in healthy and diseased skeletal muscle and their roles in cancer. Skeletal muscle is an archetypal adult stem cell model, in which maintenance, growth and repair of functionally specialised post-mitotic cells is achieved by recruitment of undifferentiated precursors. The functional unit of a skeletal muscle is the myofibre: a giant syncytial cell maintained by hundreds of post-mitotic myonuclei. The routine needs for myonuclear homeostasis, together with the more sporadic demands for hypertrophy and repair, are performed by muscle satellite cells. These resident stem cells are normally mitotically quiescent in mature muscle, and so must first be activated to undergo extensive proliferation to generate myoblasts that eventually differentiate to provide new myonuclei. In muscle wasting diseases such as muscular dystrophies though, this regenerative capacity is gradually degraded.
Research Interests
Papers共 85 篇Author StatisticsCo-AuthorSimilar Experts
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iScienceno. 6 (2024): 109947-109947
Thuy-Hang Nguyen, Lise Paprzycki,Alexandre Legrand,Anne-Emilie Decleves,Philipp Heher, Maelle Limpens,Alexandra Belayew,Christopher R. S. Banerji,Peter S. Zammit,Alexandra Tassin
SKELETAL MUSCLEno. 1 (2023)
Human Molecular Genetics (2023): 182-197
ACS applied polymer materialsno. 11 (2022): 8193-8202
P Heher, M Ganassi,A Weidinger, EN Engquist, J Pruller,TH Nguyen,A Tassin, AE Declèves,K Mamchaoui,J Grillari,AV Kozlov,PS Zammit
biorxiv(2021)
Huascar Pedro Ortuste Quiroga,Massimo Ganassi,Shingo Yokoyama,Kodai Nakamura,Tomohiro Yamashita,Daniel Raimbach, Arisa Hagiwara, Oscar Harrington, Jodie Breach-Teji,Atsushi Asakura,Yoshiro Suzuki,Makoto Tominaga,
Cellsno. 3 (2021): 393
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Author Statistics
#Papers: 83
#Citation: 5774
H-Index: 29
G-Index: 63
Sociability: 6
Diversity: 3
Activity: 19
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