基本信息
浏览量:18
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My laboratory is interested in developing neuroprotective agents targeting neurodegeneration associated with stroke and cerebrovascular diseases. We have previously shown that –(-)epicatechin, a polyphenolic compound found abundantly in dark chocolates, has neuroprotective properties and salvages dying neurons in the penumbra region of stroke, wherein cells are half dead and half alive and can be saved by timely intervention by targeting particular genes or molecules. To further delineate the mechanism of action of these potential neuroprotective agents, we are interested in evaluating how these compounds up-regulate antioxidant gene, Heme-oxygenase-1 (HO-1), which has been shown to provide neuroprotection in various ischemic models. We are also aware that HO1 is up-regulated by Nrf2, a transcription factor that has been shown to up-regulate a battery of antioxidant genes in stressful situations and strengthen defense mechanisms. Therefore, it is imperative to study the role of the HO1/Nrf2 pathway as a mechanism involved in the protection provided by these neuroprotective agents. To studying these novel compounds, we have developed in vivo [Middle Cerebral Artery Occlusion (t-MCAO); Permanent Distal Middle Cerebral Artery Occlusion (pMCAO); and Delayed Hippocampal Neuronal Death in global ischemia (BCCAO)] and in vitro [Oxygen-glucose deprivation (OGD); cell death models] working models of ischemia. These models simulate the conditions of human stroke and provide us alternatives to study the mechanism of stroke and test therapeutic potential of novel neuroprotective agents. These studies may provide a unique contribution for the treatment of stroke and ischemic brain injury and contribute to public health in the United States as well as globally.
研究兴趣
论文共 166 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mohammad I. Yatoo,Ghaith A. Bahader, Shafayat A. Beigh, Adil M. Khan,Antonisamy William James, Maleha R. Asmi,Zahoor A. Shah
Modern Physics Letters B (2024)
Ghaith A. Bahader, Farzaneh Naghavi, Ahmed Alotaibi, Amir Dehghan, Caroline C. Swain,James P. Burkett,Zahoor A. Shah
BIOMEDICINESno. 3 (2024)
The European Physical Journal Plusno. 2 (2024): 1-25
TRIBOLOGY INTERNATIONAL (2024): 109457
Biomedicinesno. 3 (2024)
Zahoor Shah, S. Bilal,Muhammad Asif Zahoor Raja,Waqar Azeem Khan, Raja Zaki Haider,Shumaila Javeed,Taseer Muhammad
Alexandria Engineering Journal (2024): 130-146
Shahzada Mudasir Rashid,Rahil Razak, Aabid Khaliq Tantra,Antonisamy William James, Nuzhat Showkat,Faheem Shehjar,Fatimah Jan,Sheikh Bilal Ahmad,Andleeb Khan,Zahoor A. Shah
crossref(2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn