基本信息
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Career Trajectory
Bio
I am a pediatric physician-scientist striving to advance cystic fibrosis clinical care and translational research. Clinically, I am focused on gastrointestinal manifestations of cystic fibrosis, developing diagnostic and therapeutic modalities to improve the gastrointestinal and liver health of those with cystic fibrosis. I also specialize in the clinical management of pediatric pancreatitis and am involved with the international INSPPIRE consortium to study pediatric pancreatitis. My research spans the entire spectrum across basic science and translational research to clinical research and trials. In the laboratory, my projects are centered around understanding mechanisms of ion transport in cystic fibrosis tissues and determining how loss of CFTR ion transport leads to pathologic changes in human physiology. We are also very interested in the pathophysiological relationship between pancreatitis and intestinal diseases, such as inflammatory bowel disease. Our laboratory has expertise in epithelial ion transport, with specialized skills in the measurement of bicarbonate transport. We are also part of a Multi-PI collaboration pursuing CFTR gene editing and stem cell engraftment for the treatment of cystic fibrosis. We utilize a combination of immortalized and primary cell culture, organoids, mouse and human tissue, and whole animal in vivo studies.
Research Interests
Papers共 106 篇Author StatisticsCo-AuthorSimilar Experts
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Jessica B. Sarthi, Annie M. Trumbull,Shayda M. Abazari,Vincent van Unen,Joshua E. Chan, Yanfen Jiang,Jesse Gammons,Marc O. Anderson,Onur Cil,Calvin J. Kuo,Zachary M. Sellers
biorxiv(2024)
Alvin Jay Freeman,Kenneth Ng, Fuchenchu Wang,Maisam A Abu-El-Haija,Ankur Chugh,Gretchen A Cress,Douglas S Fishman, Cheryl E Gariepy, Matthew J Giefer,Praveen Goday,Tanja Y Gonska,Amit S Grover,
The American journal of gastroenterology (2024)
Jessica B Sarthi, Annie M Trumbull,Shayda M Abazari,Vincent van Unen,Joshua E Chan, Yanfen Jiang,Jesse Gammons,Marc O Anderson,Onur Cil,Calvin J Kuo,Zachary M Sellers
bioRxiv : the preprint server for biology (2024)
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITIONno. 4 (2023): 540-546
American journal of physiology. Lung cellular and molecular physiologyno. 6 (2023): L771-L782
Zachary M. Sellers, Michael Wilschanski
CRC Press eBookspp.331-339, (2023)
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]no. 7 (2023): 755-760
Journal of Cystic Fibrosis (2023): S86-S87
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