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Why can some people tolerate exposure to DNA damaging agents such as radiation, sunlight, reactive oxygen species and tobacco smoke, while others develop disease? Why do some cancers respond to radiation and chemotherapy, while others do not? Research in the Nagel lab is focused on finding answers to these questions by studying DNA repair. We are using novel multiplex, cell-based DNA repair assays (FM-HCR) together with biochemical and biophysical approaches to understand DNA repair at the molecular, cellular and population levels, with the long-term goal of advancing personalized prevention and treatment of disease.
One area of research is focused on defining the structural and mechanistic biology of the molecular machines that repair DNA damage. This project is aimed at understanding how mutations affect the function of DNA repair complexes, and identifying cancer-specific therapeutic targets.
Why can some people tolerate exposure to DNA damaging agents such as radiation, sunlight, reactive oxygen species and tobacco smoke, while others develop disease? Why do some cancers respond to radiation and chemotherapy, while others do not? Research in the Nagel lab is focused on finding answers to these questions by studying DNA repair. We are using novel multiplex, cell-based DNA repair assays (FM-HCR) together with biochemical and biophysical approaches to understand DNA repair at the molecular, cellular and population levels, with the long-term goal of advancing personalized prevention and treatment of disease.
One area of research is focused on defining the structural and mechanistic biology of the molecular machines that repair DNA damage. This project is aimed at understanding how mutations affect the function of DNA repair complexes, and identifying cancer-specific therapeutic targets.
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论文共 68 篇作者统计合作学者相似作者
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Gergely Rona,Bearach Miwatani-Minter,Qingyue Zhang, Hailey V. Goldberg, Marc A. Kerzhnerman, Jesse B. Howard,Daniele Simoneschi, Ethan Lane, John W. Hobbs,Elizabeth Sassani,Andrew A. Wang,Sarah Keegan,
Molecular Cell (2024)
Daniel J Laverty,Shiv K Gupta, Gary A Bradshaw, Alexander S Hunter,Brett L Carlson, Nery Matias Calmo,Jiajia Chen,Shulan Tian, Jann N Sarkaria,Zachary D Nagel
Nature communicationsno. 1 (2024): 5294-5294
The Journal of biological chemistrypp.107579-107579, (2024)
Jiajia Chen,Daniel J Laverty,Surabhi Talele, Ashwin Bale,Brett L Carlson,Kendra A Porath,Katrina K Bakken,Danielle M Burgenske,Paul A Decker,Rachael A Vaubel,Jeanette E Eckel-Passow, Rohit Bhargava,
Science translational medicineno. 734 (2024): eadj5962-eadj5962
Genetics Population Genetics - From DNA to Evolutionary Biology (2024)
Needa Brown,Paul Rocchi, Léna Carmès,Romy Guthier,Meghna Iyer,Léa Seban, Toby Morris,Stephanie Bennett, Michael Lavelle,Johany Penailillo,Ruben Carrasco, Chris Williams,
Theranosticsno. 14 (2023): 4711-4729
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 60-61
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