The team was created in 2007 by Pr Yves Lévy and is studying HIV pathophysiology from upstream to translational research in the field of immune interventions and vaccines. The research activity of the team is closely linked to the department of clinical immunopathology. This department has been involved in more than 20 clinical trials in the field of HIV and primary immunodeficiencies, and more than 1000 HIV-infected patients are followed in this clinical department. In 2007, the clinical department extended its clinical research program by the creation of a Clinical Center of HIV Vaccinology aiming at recruiting healthy volunteers and developing an HIV-vaccine clinical trials program. Therefore, extensive clinical opportunities have been available, allowing thus the group to extensively publish on the topic of Immune-Based Therapies and HIV physiopathology.