My research interests focus on the immunologic and genetic mechanisms of lymphomagenesis, particularly in the setting of HIV infection. While hematologic malignancies and lymphoproliferative disorders (including Multicentric Castleman Disease) in sub-Saharan Africa arise under intrinsic and extrinsic pressures very different from those in the United States, comprehensive analyses of these diseases have not been performed. Our laboratory group uses advanced sequencing, immunophenotypic and cellular analyses to address gaps in our understanding of lymphomagenesis and tumor microenvironment in the context of HIV-associated immune dysregulation. Deciphering these tumor-host interactions is critical to better tailor treatment and improve outcomes, particularly in the era of cancer immunotherapy.