基本信息
浏览量:64
职业迁徙
个人简介
Research Interests:
On one hand, receptors and ion channels are key units in cell membrane, and the dysfunction of receptors and ion channels is the important basis of human diseases, and they are major drug targets. On the other hand, living strategies for prey capture and defense have evolved extensive diverse protein and peptide toxins in venomous animals in nature. These biotoxins are characterized by 1) strong activity (acting in pM and nM); 2) high specificity (effectively on subtype of the receptors and ion channels); 3) huge molecular diversity (multiple-gene copy families). They have been widely used as 1) powerful research tools in exploring human patho-physiology, 2) important clinic therapeutics, 3) templates for clinic drug design.
Objective: Dr. Zhang’s Lab carries out long-term, systemic research on the bio-diversity and the structure and function of protein and peptide biotoxins from various animals. At present stage, the work of Dr Zhang's Lab mainly focuses on the biotoxins from amphibians, reptiles and centipedes. Major efforts are projects that will lead to the elucidation of bio-diversity of animal toxin proteins and peptides, their biological targets, action mechanisms involved and biological implications. Such studies hopefully to provide useful information and research tools for biological and biomedical research, and will eventually help to illustrate the human patho-physiology and disease mechanisms. On the basis above, potential drug leads finding, rational new molecule design and clinic utilization are perspective.
On one hand, receptors and ion channels are key units in cell membrane, and the dysfunction of receptors and ion channels is the important basis of human diseases, and they are major drug targets. On the other hand, living strategies for prey capture and defense have evolved extensive diverse protein and peptide toxins in venomous animals in nature. These biotoxins are characterized by 1) strong activity (acting in pM and nM); 2) high specificity (effectively on subtype of the receptors and ion channels); 3) huge molecular diversity (multiple-gene copy families). They have been widely used as 1) powerful research tools in exploring human patho-physiology, 2) important clinic therapeutics, 3) templates for clinic drug design.
Objective: Dr. Zhang’s Lab carries out long-term, systemic research on the bio-diversity and the structure and function of protein and peptide biotoxins from various animals. At present stage, the work of Dr Zhang's Lab mainly focuses on the biotoxins from amphibians, reptiles and centipedes. Major efforts are projects that will lead to the elucidation of bio-diversity of animal toxin proteins and peptides, their biological targets, action mechanisms involved and biological implications. Such studies hopefully to provide useful information and research tools for biological and biomedical research, and will eventually help to illustrate the human patho-physiology and disease mechanisms. On the basis above, potential drug leads finding, rational new molecule design and clinic utilization are perspective.
研究兴趣
论文共 295 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yinyin Yang, Zhongwei Yu,Zufang Ba,Xu Ouyang,Beibei Li, Ping Yang,Jingying Zhang,Yu Wang, Yao Liu,Tingting Yang,Yuhuan Zhao, Xiaoyan Wu,
Beibei Li,Xu Ouyang, Yao Liu,Zufang Ba,Yinyin Yang,Jingying Zhang, Ping Yang,Tingting Yang,Yu Wang,Yuhuan Zhao,Wenbo Mao,Chao Zhong,
Yun Zhang,Lijun Du,Chenxi Wang, Zhangsheng Jiang, Qingchi Duan, Yiping Li,Zhijun Xie,Zhixing He,Yi Sun,Lin Huang,Liwei Lu,Chengping Wen
Signal Transduction and Targeted Therapyno. 1 (2024): 18-18
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY (2023): 111739-111739
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 10 (2023)
iScienceno. 5 (2023): 106598
引用2浏览0WOS引用
2
0
The Journal of biological chemistrypp.104717, (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn