张运晓 - College of Chemistry, Zhengzhou University

基本信息

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职业迁徙

个人简介

研究方向
1. 抗癌药物的设计合成
2. 抗神经退化药物及分子探针的设计合成
专业领域

有机化学：功能分子的设计、合成

药物化学：药物分子的设计、合成及生物活性评价；创新药物研发。

研究兴趣

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Evaluation of Plasma Neurodegenerative Biomarkers for Diagnosing Minimal Hepatic Encephalopathy and Predicting Overt Hepatic Encephalopathy in Chinese Patients with Hepatic Cirrhosis

Qiuyu Cheng, Yunhui Liu, Zhongyuan Yang, Meng Zhang, Tingting Liu, Yuxin Niu,Wei Liu, Lanyue Huang, Yuzhao Feng,Xiaoyun Zhang,Xiaoping Luo,Qin Ning,Tao Chen

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGYno. 1 (2025): 35-46

引用0浏览0WOS引用

In Vitro Inhibition of Α-Synuclein Aggregation and Disaggregation of Preformed Fibers by Polyphenol Hybrids with 2-Conjugated Benzothiazole

Ya-Dong Zhao,Wei Zhang,Li-Zi Xing,Ji Xu, Wei-Min Shi,Yun-Xiao Zhang

Bioorganic & Medicinal Chemistry Letters（2024）

引用2浏览0WOS引用

Therapeutic Potential of Coumarin-polyphenolic Acid Hybrids in PD: Inhibition of Α-Syn Aggregation and Disaggregation of Preformed Fibrils, Leading to Reduced Neuronal Inclusion Formation

Zhen-Ping Wang,Wei Zhang,Li-Zi Xing,Ya-Dong Zhao,Ji Xu,Yun-Xiao Zhang

Bioorganic & Medicinal Chemistry Letters (2024): 129618-129618

引用3浏览0WOS引用

Pyrazolamide Derivatives Inhibit Α-Synuclein Aggregation, Disaggregate Preformed Fibers, and Reduce Inclusion Formation in Neuron Cells

Li-Zi Xing,Wei Zhang,Ya-Dong Zhao,Ji Xu,Yun-Xiao Zhang

European Journal of Medicinal Chemistry (2024): 116198-116198

引用4浏览0WOS引用

4-Arylidene Curcumin Derivatives in Vitro Inhibit Α-Synuclein Aggregation and Disaggregate the Preformed Fibril

Wei Liu,Wei Zhang,Li-Zi Xing,Ya-Dong Zhao,Ji Xu,Rui-Jun Li,Yun-Xiao Zhang

BIOORGANIC & MEDICINAL CHEMISTRY (2023)

引用6浏览0WOS引用

Hybrids of Polyphenolic/quinone Acids, the Potential Preventive and Therapeutic Drugs for PD: Disaggregate Α-Syn Fibrils, Inhibit Inclusions, and Repair Damaged Neurons in Mice

Ming-Huan Lu,Zhen-Ping Wang,Li-Zi Xing,Wei Zhang,Feng Han,Guo-Long Huang,Wei Liu,Yun-Xiao Zhang,Ji Xu,Jinquan Cui

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2023）

引用7浏览0WOS引用

The Potential of Rhein's Aromatic Amines for Parkinson's Disease Prevention and Treatment: Α-Synuclein Aggregation Inhibition and Disaggregation of Preformed Fibers

Wei Zhang,Wei Liu,Ya-Dong Zhao,Li-Zi Xing,Ji Xu,Rui-Jun Li,Yun-Xiao Zhang

Bioorganic & Medicinal Chemistry Letters (2023): 129564-129564

引用6浏览0WOS引用

Selective Oxidative Cleavage of the C–C Bond in Α,β-Epoxy Ketone into Carbonyl Compounds

Bing Jiang,Huai-Zhu Li,Rui-Jun Li,Jianye Zhang,Yun-Xiao Zhang

ACS Omega（2022）

引用0浏览0WOS引用

Hybrids of Polyphenolic Acids and Xanthone, the Potential Preventive and Therapeutic Effects on PD: Design, Synthesis, in Vitro Anti-Aggregation of Α-Synuclein, and Disaggregation Against the Existed Α-Synuclein Oligomer and Fibril

Feng Han,Bing Jiang,Ming-Huan Lue,Zhen-Ping Wang,Wei Liu,Yun-Xiao Zhang,Ji Xu

Bioorganic & Medicinal Chemistry（2022）

引用9浏览0WOS引用

Bis-chalcone Polyphenols with Potential Preventive and Therapeutic Effects on PD: Design, Synthesis and in Vitro Disaggregation Activity Against Α-Synuclein Oligomers and Fibrils

Bing Jiang,Feng Han,Ming-Huan Lu,Zhen-Ping Wang,Wei Liu,Yun-Xiao Zhang,Ji Xu,Rui-Jun Li

European Journal of Medicinal Chemistry (2022): 114529-114529

引用11浏览0WOS引用

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Yunxiao Zhang(张运晓)

副教授

论文共 43 篇作者统计合作学者相似作者