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The main focus of my research is to understand the fundamental role of phospholipids and their oxygenated species in cell death pathways including apoptosis, necroptosis, ferroptosis and mitophagy. My studies discovered that the generation of cardiolipin oxygenated species is essential for the execution of the apoptotic cell death pathway and provide insight into the role of reactive oxygen species in triggering cell death pathways. My significant contribution to a study on the mechanisms responsible for the degradation of injured mitochondria by macroautophagy resulted in the discovery of a new regulatory pathway involved in the quality control of mitochondria realized via elimination of damaged organelles. Particularly, redistribution of cardiolipin from the inner to the outer mitochondrial membrane serves as an “eat-me” signal for the elimination of damaged mitochondria in cells. In addition, my contribution to the investigation of the role of lipid hydroperoxides in ferroptosis revealed a complex lipid oxidation signature associated with the ferroptotic cell death pathway.
Research Interests
Papers共 317 篇Author StatisticsCo-AuthorSimilar Experts
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Angewandte Chemie (International ed. in English)no. 9 (2024): e202314710-e202314710
Kazuhiro Yamada,Claudette St Croix,Donna B Stolz,Yulia Y Tyurina,Vladimir A Tyurin, Laura R Bradley,Alexander A Kapralov,Yanhan Deng,Xiuxia Zhou, Qi Wei, Bo Liao, Nobuhiko Fukuda,
Nature communicationsno. 1 (2024): 5818-5818
Evgenii N Tcyganov,Taekyoung Kwak,Xue Yang, Adi Narayana Reddy Poli,Colin Hart,Avishek Bhuniya,Joel Cassel,Andrew Kossenkov,Noam Auslander,Lily Lu,Paridhima Sharma, Maria De Grecia Cauti Mendoza,
bioRxiv : the preprint server for biology (2024)
Patrizia Agostinis,Maria Livia Sassano,Yulia (Y) Tyurina, Antigoni Diometzidou, Ellen Vervoort,Vladimir Tyurin,Sanket More,Rita La Rovere,Francesca Giordano,Geert Bultynck,Hülya Bayir,Valerian (E) Kagan,
crossref(2024)
Brandon Richter, Michael Epperly,Yulia Tyurina, Galina Shurin, Carla Johnson, Aybike Korkmaz, Yuan Gao, Julie Scott,Joel Greenberger,Valerian Kagan,Hülya Bayır
Biochimica et biophysica acta. Molecular basis of diseasepp.167434-167434, (2024)
Oncoimmunologyno. 1 (2023): 2192098
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