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A fundamental question in understanding tissue development is how resident stem cells or multipotent progenitors give rise to the various cell types in appropriate numbers and at the right locations to achieve tissue organization. Our laboratory has been studying the mechanisms and logic that underlie the regulation of neural stem/progenitor cell fate both during embryonic brain development and in the adult brain. Our current research foci include the genetic and epigenetic regulation of neural stem/progenitor cell fate and neuronal maturation, the genesis and maintenance of adult neural stem cells, and the relevance of neural stem/progenitor cell dysregulation in neurodevelopmental disorders such as autism spectrum disorders.
A fundamental question in understanding tissue development is how resident stem cells or multipotent progenitors give rise to the various cell types in appropriate numbers and at the right locations to achieve tissue organization. Our laboratory has been studying the mechanisms and logic that underlie the regulation of neural stem/progenitor cell fate both during embryonic brain development and in the adult brain. Our current research foci include the genetic and epigenetic regulation of neural stem/progenitor cell fate and neuronal maturation, the genesis and maintenance of adult neural stem cells, and the relevance of neural stem/progenitor cell dysregulation in neurodevelopmental disorders such as autism spectrum disorders.
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