基本信息
浏览量:18
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My research aims to identify functional RNA elements in transcriptomes through genome-wide detection of RNA structures. RNA play an important role in regulating cellular gene expression. Its ability to fold into complex secondary and tertiary structures is fundamental to its function in the cell. In almost every step of its life cycle, RNA structure has been found to influence diverse processes including transcription, translation mRNA transcript and decay. Alterations in RNA structure have been implicated in several diseases. Despite the importance of RNA structure, structural information for most cellular RNAs, such as mRNAs, is lacking due to the low throughput nature of RNA structure probing and difficulties in probing long RNAs. To fully assess the impact of RNA structure in biology, I aim to utilize and extend high throughput ways to probe RNA structures in solution by coupling structure probing to high throughput sequencing. This enables us to probe RNA structures for thousands of RNAs simultaneously. This expansion of RNA structural data will likely enhance our understanding of how RNA function in different cellular systems, as well as open doors to potentially targeting these structural elements in diseases.
研究兴趣
论文共 57 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Ayça Altay Benetti, Eugene Yang Zhi Tan,Zi Wei Chang,Ki Hyun Bae, Ma Thinzar Thwin,Ram Pravin Kumar Muthuramalingam,Kuo-Chieh Liao,Yue Wan,Lisa F P Ng,Laurent Renia, Jianping Liu,Xiaoyuan Chen,
CoRR (2024)
引用0浏览0EI引用
0
0
Jiaxu Wang, Lin Yang, Anthony Cheng, Cheng-Yong Tham, Wenting Tan, Jefferson Darmawan,Paola Florez de Sessions,Yue Wan
Nature Communicationsno. 1 (2024): 1-10
Nature reviews. Molecular cell biologypp.1-18, (2024)
Benjamin William Walters,Tiak Ju Tan,Chew Teng Tan,Christabel Thembela Dube, Kang Ting Lee,Jace Koh,Yasmin Hui Binn Ong, Vanessa Xue Hui Tan, Fathima Rifkhana Shah Jahan,Xin Ni Lim,Yue Wan,Chin Yan Lim
Kuo-Chieh Liao,Xuping Xie, Anna Karin Beatrice Sundstrom,Xin Ni Lim, Kiat Kee Tan,Yu Zhang,Jing Zou,Amanda Makha Bifani,Hui Xian Poh,Jia Jia Chen,Wy Ching Ng,Su Ying Lim,
Genome biologyno. 1 (2023): 279-279
Wei-Xin Chin,Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk,Regina Ching Hua Lee,Si Xian Ho,Zhen Qin Aw,Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan,Thinesshwary Yogarajah,
PLoS pathogensno. 10 (2023): e1011753-e1011753
bioRxiv (Cold Spring Harbor Laboratory) (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn