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Dr. Zhu has contributed significantly to the understanding of the cellular and mechanism underlying the pathogenesis of neurofibromatosis type 1 (NF1)-associated diseases, the role of tumor suppressor genes in normal development and brain tumorigenesis. Dr. Zhu has developed a series of genetically engineered mouse (GEM) models for a variety of NF1-associated diseases, including plexiform neurofibroma, malignant peripheral nerve sheath tumor (MPNST), low- and high-grade gliomas. Some or derivatives of these GEM models were used for the preclinical studies, serving the basis for the success of clinical trials using MEK inhibitors for plexiform neurofibroma. Further, Dr. Zhu’s group is one of the researcher groups that showed therapeutic efficacy of MEKi in treating NF1-associated diseases.
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Thomas U. Marron,Laura Brennan,Pauline Hamon,Maria Isabel Fiel, Stephen C. Ward,Yuan O. Zhu,Edward Kim,Alice O. Kamphorst,Pradeep Thanigaimani,Thomas S. Uldrick, Natalie Lucas, Kathy Wu,
CANCER RESEARCHno. 7 (2023)
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Neuro-oncologyno. 11 (2023): 1920-1931
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