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职业迁徙
个人简介
Our research interests are in translational research. We aim at translating the promise of genomic medicine into clinical reality.
Current research projects:
1). Identification of novel genes/targets associated with adverse drug reactions and some common multi-factorial diseases such as type II diabetes mellitus, bipolar disorder and Kawasaki disease.
2). Genetics and molecular mechanisms of Stevens-Johnson syndrome, a life-threatening cutaneous adverse drug reaction. We are investigating how the specific HLA allele and the T cell receptor mediating the cell toxicity in causing disseminated keratinocyte death.
3). Improved therapy for Pompe disease, a debilitating, progressive and often fatal myopathy. The enzyme replacement therapy for Pompe disease has dramatically improved the outcome of the disease; however, limitations of the therapy such as neutralizing antibody and variable skeletal response remain a challenge. We are continuing to explore various strategies to improve the therapies.
研究兴趣
论文共 239 篇作者统计合作学者相似作者
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Ken Suzuki,Konstantinos Hatzikotoulas,Lorraine Southam, Henry J Taylor,Xianyong Yin,Kim M Lorenz,Ravi Mandla,Alicia Huerta-Chagoya, Nigel W Rayner,Ozvan Bocher, Ana Luiza de S V Arruda,Kyuto Sonehara,
medRxiv : the preprint server for health sciences (2023)
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Chia-Hui Lo,Deng-Chyang Wu,Shu-Wen Jao,Chang-Chieh Wu,Chung-Yen Lin,Chia-Hsien Chuang, Ya-Bo Lin,Chien-Hsiun Chen,Ying-Ting Chen, Jiann-Hwa Chen,Koung-Hung Hsiao,Ying-Ju Chen,
Emery and Rimoin's Principles and Practice of Medical Genetics and Genomicspp.105-156, (2021)
user-5f165ac04c775ed682f5819f(2020)
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