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The goal of research in the Yamaguchi laboratory is to understand the role of proteoglycans and glycosaminoglycans in the context of development and human disorders. The general strategy is to define the role of proteoglycans and glycosaminoglycans by characterizing the phenotype of mutant mice lacking the synthesis of individual glycosaminoglycans. Specifically, mutant mice lacking the Ext1 and Has genes have been created to study heparan sulfate and hyaluronan, respectively. Recent progress in genetic studies in humans and mice has begun to reveal that deficiencies in glycosaminoglycans can be the causes and/or confounding factors of human childhood disorders. The Yamaguchi lab is now working to clarify the molecular mechanisms of two such disorders (multiple hereditary exostoses and autism) in order to develop new medical treatments.
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论文共 107 篇作者统计合作学者相似作者
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Monica Gamez, Hesham E. Elhegni,Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell,David A. Copland,Karen L. Onions,Matthew J. Butler, Elizabeth J. Wasson,Michael Crompton,Raina D. Ramnath,Yan Qiu,
Cardiovascular Diabetologyno. 1 (2024): 1-1
Ayumi Niwa,Toshiaki Taniguchi,Hiroyuki Tomita,Hideshi Okada,Takamasa Kinoshita, Chika Mizutani,Mikiko Matsuo,Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi,Takaaki Sugiyama,Tomohiro Kanayama,
Takuma Narita,Yuki Tobisawa, Andrey Bobkov, Michael Jackson,Chikara Ohyama,Fumitoshi Irie,Yu Yamaguchi
The Journal of biological chemistryno. 9 (2023): 105120-105120
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Sandra Abril Herrera-Heredia,Hsuan-Po Hsu,Cheng-Yen Kao, Yu-Huan Tsai,Yu Yamaguchi,Axel Roers,Chia-Lin Hsu,Ivan L. L. Dzhagalov
Hsuan-Po Hsu, Yun-Tzu Chen,Yu-Ying Chen,Chih-Yu Lin,Po-Yu Chen, Shio-Yi Liao,Ciara Christianne Y Lim,Yu Yamaguchi,Chia-Lin Hsu,Ivan L Dzhagalov
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