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职业迁徙
个人简介
Research Interests:
Our group works on two related research topics: 1) Small RNA processing mechanisms 2) Host-Pathogen interactions by the combinations of X-ray, NMR, Cryo-EM with genetic tools.
1) Small RNA processing mechanisms
Small RNA plays significant roles for gene regulations both in eukaryotic and prokaryotic systems. Currently we are focusing on several large protein-RNA complexes involved in this pathway. We are focusing on the structural characterization of holo-RISC in Arabidopsis, human systems and CRISPR processing machineries in bacterial systems by the combination of proteomics, biophysics and genetics tools. Such efforts would eventually open a new avenue to understand the small RNA processing mechanisms in vitro and in vivo.
2) Host-Pathogen interactions
In addition to eukaryotic and prokaryotic systems, virus is another living species. Many viruses are harmful to plants, animals and human. Our current research focuses are on virus structure determination, screening of neutralization antibodies and vaccine development by the combination of structural biology and protein engineering. We also plan to use high-resolution bioimaging tools to directly visualize the virus infection process at single molecular level. Such efforts will open a new avenue to understand the host-pathogen interaction and provide new strategy to fight against virus infection. We have made considerable progress on vaccine development against several important animal and human viruses.
Our group works on two related research topics: 1) Small RNA processing mechanisms 2) Host-Pathogen interactions by the combinations of X-ray, NMR, Cryo-EM with genetic tools.
1) Small RNA processing mechanisms
Small RNA plays significant roles for gene regulations both in eukaryotic and prokaryotic systems. Currently we are focusing on several large protein-RNA complexes involved in this pathway. We are focusing on the structural characterization of holo-RISC in Arabidopsis, human systems and CRISPR processing machineries in bacterial systems by the combination of proteomics, biophysics and genetics tools. Such efforts would eventually open a new avenue to understand the small RNA processing mechanisms in vitro and in vivo.
2) Host-Pathogen interactions
In addition to eukaryotic and prokaryotic systems, virus is another living species. Many viruses are harmful to plants, animals and human. Our current research focuses are on virus structure determination, screening of neutralization antibodies and vaccine development by the combination of structural biology and protein engineering. We also plan to use high-resolution bioimaging tools to directly visualize the virus infection process at single molecular level. Such efforts will open a new avenue to understand the host-pathogen interaction and provide new strategy to fight against virus infection. We have made considerable progress on vaccine development against several important animal and human viruses.
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