His research focused mainly on the development of novel bio-lasers, from molecular, cellular, to tissue level for next generation biomedical applications. Since 2012 he has already published more than 60 top journals and proceedings, including Nature Biomedical Engineering, ACS Nano, Advanced Science, Optica. His research was reported by more than 200 media and news worldwide, including "Nature Reviews", “The New Scientists”, “RSC-Chemistry World”, “Daily Mail”, “BioOptics World”, “Phys.Org.”, etc. Being as the pioneer in the field of Biolasers, he has achieved several breakthroughs, including several types of biolasers at the tissue level, which pointed out future direction using lasing emission for on-chip disease diagnosis and cancer detection. He invented the first laser-emission microscopy, a novel imaging modality that can be widely applied to bio-devices, cancer immunodiagnostics, and neuro-analysis. These breakthroughs represent a critical milestone to implement biolasers in biomedical imaging, which opens a door to a plethora of applications in translation research of laser-emission microscopy, precision medicine and fundamental biology.