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Professor Nagahama has been an eminent leader of reproductive endocrinology in vertebrates, mainly fish. He was quick to recognize the power of molecular biology techniques, and his laboratory was one of the first non-mammalian laboratories to focus on molecular endocrinology. Professor Nagahama’s main research interests focus on determining the molecular and cellular events related to sex determination/differentiation, sexual plasticity and gametogenesis. The major contributions of his laboratory in gametogenesis include the first identification of spermatogenesis-inducing hormone and oocyte/sperm maturation-inducing hormones using fishes. The achievement of complete spermatogenesis from spermatogonia to mature sperm under in vitro organ culture conditions provided extensive insights to understand entire events of spermatogenesis for the first time. These hormones have been used for artificial induction of gamete maturation and spawning of some of commercially important fish such as Japanese eel in captivity. More recently, his laboratory expanded their work to invertebrates by the first identification of gonadotropin in invertebrates, gonad-stimulating substance of starfish, to be a member of relaxin family.
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Fish Physiology (2023)
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Yuji Nishiike,Daichi Miyazoe, Rie Togawa,Keiko Yokoyama,Kiyoshi Nakasone, Masayoshi Miyata,Yukiko Kikuchi,Yasuhiro Kamei,Takeshi Todo,Tomoko Ishikawa-Fujiwara,Kaoru Ohno,Takeshi Usami,
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