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Research Interest
1. Mechanisms of Resistance to targeted therapy in human melanoma.
Acquired and/or adaptive resistance to small molecule inhibitor drugs represents a major hurdle for improvement of clinical benefits in targeted cancer therapy. Using human melanoma as a cancer model, we are interested in the mechanisms of the development of acquired or adaptive resistance to RAF or MEK inhibitors.
2. The function and regulatory mechanism of protein posttranslational modification.
Protein posttranslational modification plays important roles in the regulation of protein functions and in cancer development. Using a combinational approach of protein chemical synthesis, mass spectrometry, crystallography etc, we aim to identify novel posttranslational modifications of several cancer-related proteins such as SOX10, CIC and β-Catenin, investigate their biological implications in cancer development as well as their regulation modes.
3. DC-based cellular immunotherapy platform
Cellular immunotherapy is an innovative treatment approach that harness the patient’s own immune system to fight cancer. Dendritic cells (DCs) are the most potent antigen presenting cells in human body and can be potentially used as tumor-antigen presenter to activate autologous T cells that eliminate cancer cells. We attempt to establish immortalized DC cell lines as a platform for rapid and convenient activation of autologous cytotoxic T lymphocytes to treat infectious diseases and cancer.
1. Mechanisms of Resistance to targeted therapy in human melanoma.
Acquired and/or adaptive resistance to small molecule inhibitor drugs represents a major hurdle for improvement of clinical benefits in targeted cancer therapy. Using human melanoma as a cancer model, we are interested in the mechanisms of the development of acquired or adaptive resistance to RAF or MEK inhibitors.
2. The function and regulatory mechanism of protein posttranslational modification.
Protein posttranslational modification plays important roles in the regulation of protein functions and in cancer development. Using a combinational approach of protein chemical synthesis, mass spectrometry, crystallography etc, we aim to identify novel posttranslational modifications of several cancer-related proteins such as SOX10, CIC and β-Catenin, investigate their biological implications in cancer development as well as their regulation modes.
3. DC-based cellular immunotherapy platform
Cellular immunotherapy is an innovative treatment approach that harness the patient’s own immune system to fight cancer. Dendritic cells (DCs) are the most potent antigen presenting cells in human body and can be potentially used as tumor-antigen presenter to activate autologous T cells that eliminate cancer cells. We attempt to establish immortalized DC cell lines as a platform for rapid and convenient activation of autologous cytotoxic T lymphocytes to treat infectious diseases and cancer.
Research Interests
Papers共 110 篇Author StatisticsCo-AuthorSimilar Experts
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Shujun Han, Mo Zhang, Xiaoyan Qu, Zihao Wu, Zongguan Huang,Yiming Hu,Ying Li, Lanlan Cui, Lu Si,Jiankang Liu,Yongping Shao
Oncogeneno. 6 (2024): 434-446
JOURNAL OF MATERIALS CHEMISTRY Bno. 11 (2024): 2905-2905
CURRENT EYE RESEARCHno. 7 (2023): 627-638
Qiong Sun,Le Shi,Shuaijun Li,Jialu Li, Ruifen Zhang, Xinghuai Huang,Yongping Shao,Zhihui Feng,Yunhua Peng,Zhiwei Yang, Jiankang Liu,Huadong Liu,
Free radical biology & medicine (2023): 13-24
Shujun Han,Yuwei Yan,Yibo Ren,Yiming Hu,Yan Wang,Lei Chen,Zhe Zhi,Yan Zheng,Yongping Shao, Jiankang Liu
crossref(2023)
Yan Wang,Ying Li,Yilin Gao, Jiahao Kang,Weijia Wang,Yu-Le Yong, Xiaoyan Qu,Xiaomin Dang,Dong Shang,Yongping Shao,Jiankang Liu,Ying Chang,
Ecotoxicology and Environmental Safety (2023): 115134-115134
Shujun Han,Yuwei Yan,Yibo Ren,Yiming Hu,Yan Wang,Lei Chen,Zhe Zhi,Yan Zheng,Yongping Shao, Jiankang Liu
crossref(2023)
Qiong Sun, Le Shi, Shuaijun Li, Yan Feng, Shuxia Wang, Jialu Li, Xinyue Li, Ruifen Zhang, Xinghuai Huang,Yongping Shao,Zhihui Feng,Yunhua Peng,
Research Square (Research Square) (2023)
crossref(2023)
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