We are investigating the cellular, molecular and circuit mechanism of cognitive functions such as learning-memory and social behaviors. Major research projects include:
1. Learning deficits in neurodevelopmental disorders: We are studying the mechanism and treatment for learning and memory deficits in neurodevelopmental disorders, mainly focusing on RASopathies such as Noonan syndrome and NF1. In particular, we are interested in understanding the cell-type specific signaling networks in the nervous system. You can find our reports in Nature Neuroscience (Lee et al, 2014) and Science Signaling (Ryu et al., 2019).
2. Neural circuits underlying social behaviors: We are investigating the circuit mechanism underlying social behaviors such as social recognition and social memory. Specifically, we are investigating the prefrontal projections modulating social recognition in mice. You can find our reports in Cell Reports (Park et al., 2021).
3. Non-motor cognitive functions of the cerebellum: Apart from its well-known roles in motor coordination, the cerebellum is also involved in diverse cognitive functions. We are interested in the cerebellar circuit mechanism underlying affective behaviors. This is in a strong collaboration with Prof. Sang Jeong Kim in our department.
We are using state-of-the-arts techniques such as mutant mice, optogenetics, in vivo imaging in freely moving mice, and single cell transcriptomics.